Research

Research in the Manning group follows two interconnected thrusts: Collective behavior in biological tissues and deformation in disordered solids. Click sub-topic headings below for additional detail.

Collective behavior in biological tissues
Groups of cells exhibit interesting collective behavior that emerges from simple interactions between individual cells. We searching for universal features and rules that govern this far-from-equilibrium behavior.

 

Organogenesis during development
Manning group participants:
• Gonca Erdemci-Tandogan
• Matthias Merkel

Collaborators:
• Jeff Amack (SUNY Upstate)
• Agnik Dasgupta (SUNY Upstate)

Mechanisms for compartmentalization and cell sorting in biological tissues
Manning group participants:
• Daniel Sussman
• Preeti Sahu

Collaborators:
• Jen Schwarz (SU)
• Cristina Marchetti (SU)
• Josef Kaes (Leipzig)
• Deborah Leckband (UIUC)

Rigidity in confluent 3D bulk tissues and the origin of rigidity in vertex models
Manning group participants:
• Matthias Merkel
• Daniel Sussman

Collaborators:
• Josef Käs, Andrea Liu and Tristan Sharp (U Penn)
• Jasna Brujic (NYU)
• Sevan Hopyan (U Toronto)

Tissue expansion in a wound healing strip geometry
Manning group participants:
• Michael Czajkowski
• Daniel Sussman

Collaborators:
• Cristina Marchetti (SU)

 

Flocking and pattern formation in confluent tissues
Manning group participants:
• Michael Czajkowski
• Max Dapeng Bi

Collaborators:
• Matteo Paoluzzi (SU)
• Cristina Marchetti (SU)
• Fabio Giavazzi, Giorgio Scita, and Roberto Cerbino (Milano)

Quantifying cell motion and cell polarization on 2D substrates
Manning group participants:
• Giuseppe Passucci
• M Manning

Collaborators:
• M. Brasch, J. Henderson (SU BMCE and SBI)
• Anushree Gulvady and Chris Turner (SUNY Upstate)

Deformation in disordered solids
If you push a pile of sand very lightly, it will respond elastically, but if you push beyond an extremely low threshold, it will begin to flow. But the system that it flows into will be qualitatively similar to the state it was just in. We are studying that marginal transition in low dimensional systems (2D and 3D):

What are the distinct mechanically stable states in jammed solids?
Manning group participants:
• Peter Morse
• Sven Wijtmans

Collaborators:
• Martin Van Hecke and
Merlijn Van Deen (Leiden)


Modeling jammed solids with sparse random matrices
Manning group participants:
• Ethan Stanifer
• Peter Morse

Collaborators:
• Alan Middleton (SU Physics)

 


Identifying low-frequency excitations in jammed systems
Manning group participants:
• Ethan Stanifer
• Peter Morse
• Sven Wijtmans

Collaborators:
• Alan Middleton (SU Physics)
• Eric Corwin (U Oregon)