We have posted a manuscript on BioRXiv: Xun Wang*, Matthias Merkel*, Leo B. Sutter*, Gonca Erdemci-Tandogan, M. Lisa Manning, Karen E. Kasza. “Anisotropy links cell shapes to a solid-to-fluid transition during convergent extension”, https://doi.org/10.1101/781492 (2019). In this manuscript we use a combination of vertex models and experimental analysis of convergent extension in the fruit fly to understand how the fluid-solid transition is affected by anisotropic stresses.
We posted a joint manuscript between the Manning group (Sussman, Manning) and the Gardel lab (Devaney, Gardel) on BioRXiv, titled, “Cell division Rate Controls Cell Shape Remodeling in Epithelia”, https://www.biorxiv.org/content/10.1101/804294v1. We use a combination of vertex modeling and experiments to demonstrate that cell shape (and not number density) governs cell movements in epithelia, and that cell divisions generate the dominant active stress fluctuations that cause cell movements.
Liz was accepted to study at the 2019 Boulder Summer School for Theoretical Biophysics. The program provides education for advanced graduate students and postdoctoral fellows working in condensed matter physics, materials science and related fields. Liz will be presenting her preliminary work on cellular tissues and morphogen gradients and Dr. Manning will give lectures on topics in soft matter and biophysics.
Julia was accorded an Honorable Mention in the 2019 National Science Foundation (NSF) Graduate Research Fellowship Program (GFRP) competition. Her application discussed novel models for the physics of living systems. See the SU News Article: Students Earn 2019 National Science Foundation Awards.
An abstract for contributed talk on work done by Preeti Sahu, Janice Kang, Gonca Erdemci-Tandogan, and Lisa Manning on understanding “the nature of the rigidity transition in models for ordered biological tissues” got upgraded to an invited talk for the session “Statistical Physics of Large Populations of Cells: from Microbes to Tissues II” in APS March meeting 2019. [Link]
A paper by Gonca Erdemci-Tandogan, Madeline Clark, Jeffrey Amack, and Lisa Manning titled “Tissue Flow Induces Cell Shape Changes During Organogenesis” was published in the December 4, 2018 issue of Biophysical Journal. Full text of the paper is available at https://www.cell.com/biophysj/fulltext/S0006-3495(18)31217-7
Prof. Lisa Manning was just named to Science News’ “Top 10 Scientists to Watch” list:
Congratulations to postdoctoral associate Matthias Merkel for accepting a position as an independent junior group leader at the IBDM in Marseille, France. We will miss you, but we’re so happy for your success!
Congratulations to undergraduate SBI REU student Janice Kang, who presented a poster in the University-wide Undergraduate Research Symposium in Aug 2018! Also, a big congratulations to Preeti Sahu and Gonca Erdemci Tandogan who provided mentorship on your project to quantity the nature of the rigidity transition in models for ordered biological tissues.