Our paper, “Glassy dynamics in models of confluent tissue with mitosis and apoptosis” just appeared in Soft Matter.
Recent work on particle-based models of tissues has suggested that any finite rate of cell division and cell death is sufficient to fluidize an epithelial tissue. At the same time, experimental evidence has indicated the existence of glassy dynamics in some epithelial layers despite continued cell cycling. To address this discrepancy, we quantify the role of cell birth and death on glassy states in confluent tissues using simulations of an active vertex model that includes cell motility, cell division, and cell death. Our simulation data is consistent with a simple ansatz in which the rate of cell-life cycling and the rate of relaxation of the tissue in the absence of cell cycling contribute independently and additively to the overall rate of cell motion. Specifically, we find that a glass-like regime with caging behavior indicated by subdiffusive cell displacements can be achieved in systems with sufficiently low rates of cell cycling.
Lisa was named a 2019 APS Fellow, for “microscopic theory of flow and rigidity in disordered and biological materials”, from the Division of Condensed Matter Physics. More information about the award can be found here:
On October 4, 2019, Lisa attended the UC Santa Barbara Alumni Awards reception ( https://www.ucsbalum.com/events/awards/alumni-awards-dinner ) and received the “Emerging Leader” award, for her “early career achievements in physics research and her commitment to advancing STEM to diverse audiences.”
We have posted a manuscript on BioRXiv: Xun Wang*, Matthias Merkel*, Leo B. Sutter*, Gonca Erdemci-Tandogan, M. Lisa Manning, Karen E. Kasza. “Anisotropy links cell shapes to a solid-to-fluid transition during convergent extension”, https://doi.org/10.1101/781492 (2019). In this manuscript we use a combination of vertex models and experimental analysis of convergent extension in the fruit fly to understand how the fluid-solid transition is affected by anisotropic stresses.
We posted a joint manuscript between the Manning group (Sussman, Manning) and the Gardel lab (Devaney, Gardel) on BioRXiv, titled, “Cell division Rate Controls Cell Shape Remodeling in Epithelia”, https://www.biorxiv.org/content/10.1101/804294v1. We use a combination of vertex modeling and experiments to demonstrate that cell shape (and not number density) governs cell movements in epithelia, and that cell divisions generate the dominant active stress fluctuations that cause cell movements.
Prof. Lisa Manning was just named to Science News’ “Top 10 Scientists to Watch” list:
Congratulations to postdoctoral associate Matthias Merkel for accepting a position as an independent junior group leader at the IBDM in Marseille, France. We will miss you, but we’re so happy for your success!
Congratulations to undergraduate SBI REU student Janice Kang, who presented a poster in the University-wide Undergraduate Research Symposium in Aug 2018! Also, a big congratulations to Preeti Sahu and Gonca Erdemci Tandogan who provided mentorship on your project to quantity the nature of the rigidity transition in models for ordered biological tissues.
Congratulations to Michael Czajkowski, who defended his Ph.D. thesis in Aug 2018. Best of luck in your new postdoctoral position in Zeb Rocklin’s group at Georgia Tech!