Week 1:
Aug 28, 2018. Lecture 1. Course Introduction.
Aug 30, 2018. Lecture 2. Chemical structure and building blocks. Reading: Chapter 1 of PCB, Chapter 2 of Alberts, Chapter 3 and 5 of Pollard
Week 2:
Sept 4, 2018. Lecture 3. Basic cellular functions and molecular interactions. Reading: Chapter 2 in PBC, Chapter 1 in Pollard
Sept 6, 2018. Lecture 4. Tools and Model Systems. Reading: Chapter 4 in PBC.
Week 3:
Sept 11, 2018. Lecture 5. Physics Fundamentals I. Reading, Chapter 12 in PBC.
Sept 13, 2018. Lecture 6. Physics Fundamentals II. Reading Chapter 6 and 12.
Week 4:
Sept 18, 2018. Lecture 7. Physics Fundamentals III. Statistical mechanics. Reading Chapter 6 in PBC.
Sept 20, 2018. Lecture 8. Entropy, Energy, and membranes. Reading: Chapter 5 PBC
Week 5:
Sept 25, 2018. Exam 1. In class.
Sept 27, 2018. Lecture 10. Membranes. Reading: Chapter 5 and 11 in PBC. Also see Pollard Chapter 13.
Week 6:
Oct 2, 2018. Lecture 11. Membranes and DNA. Reading: Chapter 11 in PBC.
Oct 4, 2018. Lecture 12. Membrane channels as 2-state systems. Reading: Chapter 7 in Physical Biology of the Cell.
Week 7:
Oct 9, 2018. Lecture 13. DNA structure. Reading: Chapter 12 in Pollard, Chapter 10 in PBC.
Oct 11, 2018. Lecture 14. DNA and random walks. Reading: Chapter 8 in PBC.
Week 8:
Oct 16. Lecture 15. Measuring forces on DNA/polymers. Chapter 8 in PBC.
Oct 18. Lecture 16. Diffusion and transport. Chapter 13 in PBC.
Week 9:
Oct 23. Exam 2. Cumulative, but focused on Lectures 7-15 and HW#3-6. Please see this post for information about equations for this exam.
Oct 25. Guest Lecture — Jeff Amack
Week 10:
Oct 30. Lecture 17. Cytoskeleton. Chapter 15 PBC. (with some parts of Ch 14, too)
Nov 1. Lecture 18. Rate equations (in context of cytoskeleton). Chapter 15 PBC.
Week 11:
Nov 6. Group 3 Presentation. Lecture 19. Molecular motors. Reading: PBC Chapter 16.
Nov 8. Group 7 Presentation. Lecture 20. Collective behavior of active matter. Reading: Needleman D, Dogic Z. Active matter at the interface between materials science and cell biology. Nature Reviews Materials [Internet]. 2017;2 :17048
Week 12:
Nov 13: Guest Lecture: Zhen Ma
Nov 15: Group 6 Presentation. Lecture 21. Regulatory networks and the Lac Operon. Chapter 19 PBC.
Week 13:
No classes. Thanksgiving
Week 14:
Nov 27. Lecture 22. Genetic networks 2. Chapter 19 PBC.
Nov 29. Lecture 23. Cell-cell signaling.
Week 15:
Dec 4. Guest Lecture – Liviu Movileanu
Dec 6. Lecture 24. Cell-cell signaling and adhesion. Chapter 19 PBC, and Amack and Manning. Knowing the Boundaries: Extending the Differential Adhesion Hypothesis in Embryonic Cell Sorting. Science 2012.
Final exam: Dec 11, 12:45-2:45pm